Bronchopulmonary dysplasia in patients of a kangaroo mother program in Popayán-Colombia. Retrospective cohort study
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Abstract
Kangaroo-Mother Care (KMC) is a follow-up program for premature infants with comorbidities such as bronchopulmonary dysplasia (BPD). The objective was to characterize patients with BPD and describe their nutritional, neurological, and respiratory outcomes in a KMC. A retrospective cohort study of the KMC in a University Hospital between 2015-2018. Included patients with BPD and excluded major malformations. Nutritional, neurological, and respiratory outcomes were evaluated at 40 weeks, 6, and 12 months of corrected-age using scales recommended in Colombia. A descriptive analysis was carried out, the variables were compared according to the severity of BPD. The changes in the outcomes in patients with complete follow-up were evaluated. 490 patients were admitted in four years, 50 with BPD (10,2%); 58% with moderate-BPD, none with severe BPD. 46% were born at <29 weeks of gestational-age, 96% had low socioeconomic status and 90% and 90% of these submitted to mechanical ventilation. In the follow-up, height-for-age remained at risk at 6 and 12 months. 98% had abnormal Amiel-Tisson test. Around 75% had respiratory symptoms between 6 and 12 months and 33% had at least one hospital readmission. Patients with BPD in KMC have alterations in height-for-age, neurodevelopment, and respiratory system when complete the follow-up.
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References
Sola A, Fariña D, Mir R, Golombek S. Recomendaciones del VIII consenso clínico de SIBEN para la displasia broncopulmonar. Neoreviews [Internet]. 2018;19(11):e712–34. Doi: https://doi.org/10.1542/neo.19-11-e712
Sanchez Luna M, Moreno Hernando J, Botet Mussons F, Fernández Lorenzo JR, Herranza Carrillo G, Rite Gracia S, et al. Displasia broncopulmonar: definiciones y clasificación. An Pediatr [Internet]. 2013;79(4):262.e1-262.e6. Doi: http://dx.doi.org/10.1016/j.anpedi.2013.02.003
Ruiz-Peláez JG, Charpak N. Epidemia de displasia broncopulmonar: Incidencia y factores asociados en una cohorte de niños prematuros en Bogotá, Colombia. Biomedica [Internet]. 2014;34(1):29–39. Doi: http://dx.doi.org/10.7705/biomedica.v34i1.1463
Latini G, De Felice C, Giannuzzi R, Del Vecchio A. Survival rate and prevalence of bronchopulmonary dysplasia in extremely low birth weight infants. Early Hum Dev [Internet]. 2013;89(SUPPL.1):69–73. Doi: https://doi.org/10.1016/S0378-3782(13)70020-3
Silveira Martins P, Reis de Mello R, Silveira da Silva K. Bronchopulmonary dysplasia as a predictor factor for motor alteration at 6 months corrected age in premature infants. Arq Neuropsiquiatr [Internet]. 2010;68:749–54. Doi: https://doi.org/10.1590/S0004-282X2010000500014
Reiterer F, Scheuchenegger A, Resch B, Maurer-Fellbaum U, Avian A, Urlesberger B. Bronchopulmonary dysplasia in very preterm infants: Outcome up to preschool age, in a single center of Austria. Pediatr Int [Internet]. 2019;61(4):381–7. Doi: https://doi.org/10.1111/ped.13815
Ministerio de Salud. Actualización de los Lineamientos Técnicos para la implementación de Programas Madre Canguro en Colombia, con énfasis en la nutrición del neonato prematuro o de bajo peso al nacer [Internet]. 2017. p. 1–193. Disponible en: https://fundacioncanguro.co/wp-content/uploads/2017/09/implementacion-programa-canguro.pdf
Acuña-Cordero R, Pedraza-Bernal AM, Barón-Puentes Ó. Displasia broncopulmonar. En: Posada Saldarriaga R, editor. Neumología Pediátrica. Primera ed. Bogotá D.C: Distribuna; 2016. p. 565–78.
Jobe A, Bancalari E. Bronchopulmonary dysplasia. Am J Respir Crit Care Med [Internet]. 2001;163(7):1723–9. Doi: https://doi.org/10.1164/ajrccm.163.7.2011060
WHO Anthro para computadoras personales, versión 3, 2009: Software para evaluar el crecimiento y desarrollo de los niños del mundo. [Internet]. Ginebra, OMS. 2009. Disponible en: https://www.who.int/childgrowth/software/es
Colombia. Resolución 2016. Por la cual se definen los indicadores antropométricos, los patrones de referencia y los puntos de corte para la clasificación nutricional de niños, niñas y adolescentes de 0 a 18 años de edad, adultos de 18 a 64 años de edad y [Internet]. Ministerio de Salud y Protección Social. 2016. p. 1–22. Disponible en: https://www.icbf.gov.co/sites/default/files/resolucion_no._2465_del_14_de_junio_de_2016.pdf
Amiel Tyson C, Grenier A. Neurological assessment during the first year of life. Edición ilustrada. New York: Oxford University Press; 1986.
Ellison PH, Horn JL, Browning CA. Construction of an Infant Neurological International Battery (INFANIB) for the assessment of neurological integrity in infancy. Phys Ther [Internet]. 1985;65(9):1326–31. Doi: https://doi.org/10.1093/ptj/65.9.1326
Escala Abreviada de Desarrollo - 3 [Internet]. Ministerio de Salud y Protección Social. 2017 [citado el 30 de marzo de 2021]. Disponible en: https://www.minsalud.gov.co/sites/rid/Lists/BibliotecaDigital/RIDE/VS/PP/ENT/Escala-abreviada-de-desarrollo-3.pdf
StataCorp. StataCorp. 2017. Stata Statistical Software: Release 15. College Station, TX: StataCorp LLC [Internet]. 2017. Disponible en: https://www.stata.com
RStudio Team (2021). RStudio: Integrated Development for R. RStudio, PBC, Boston, MA [Internet]. Disponible en: http://www.rstudio.com/
Colombia Ministerio de Salud. Resolución 8430 [Internet]. 1993 [citado el 30 de abril de 2021]. Disponible en: https://www.minsalud.gov.co/sites/rid/Lists/BibliotecaDigital/RIDE/DE/DIJ/RESOLUCION-8430-DE-1993.PDF
Siffel C, Kistler KD, Lewis JFM, Sarda SP. Global incidence of bronchopulmonary dysplasia among extremely preterm infants: a systematic literature review. J Matern Neonatal Med [Internet]. 2021;34(11):1721–31. Doi: https://doi.org/10.1080/14767058.2019.1646240
Jensen EA, Schmidt B. Epidemiology of bronchopulmonary dysplasia. Birth Defects Res Part A - Clin Mol Teratol [Internet]. 2014;100(3):145–57. Doi: https://doi.org/10.1002/bdra.23235
Short EJ, Kirchner HL, Asaad GR. Developmental Sequelae in Preterm Infants Having a Diagnosis of Bronchopulmonary Dysplasia. Arch Pediatr Adolesc Med [Internet]. 2007;161(11):1082–7. Doi: https://doi.org/10.1001/archpedi.161.11.1082
Gisondo CM, Donn SM. Bronchopulmonary Dysplasia: An Overview. Res Reports Neonatol [Internet]. 2020;10:67–79. Doi: http://doi.org/10.2147/RRN.S271255
Thébaud B, Goss KN, Laughon M, Whitsett JA, Steven H, Steinhorn RH, et al. Bronchopulmonary dysplasia Bernard. Nat Rev Dis Prim [Internet]. 2019;5(1):78. Doi: https://doi.org/10.1038/s41572-019-0127-7
Gagliardi L, Bellù R, Rusconi F, Merazzi D, Mosca F. Antenatal steroids and risk of bronchopulmonary dysplasia: a lack of effect or a case of over-adjustment? Paediatr Perinat Epidemiol [Internet]. 2007;21(4):347–53. Doi: https://doi.org/10.1111/j.1365-3016.2007.00814.x
Bancalari M A. Actualización en Presentación y Patogénesis de la Displasia Broncopulmonar. Rev Chil Pediatr [Internet]. 2009;80:213–24. Disponible en: https://scielo.conicyt.cl/pdf/rcp/v80n3/art02.pdf
Malavolti AM, Bassler D, Arlettaz-Mieth R, Faldella G, Latal B, Natalucci G. Bronchopulmonary dysplasia—impact of severity and timing of diagnosis on neurodevelopment of preterm infants: a retrospective cohort study. BMJ Paediatr Open [Internet]. 2018;2(1):e000165. Doi: https://doi.org/10.1136/bmjpo-2017-000165
Keszler M, Sant’Anna G. Mechanical Ventilation and Bronchopulmonary Dysplasia. Clin Perinatol [Internet]. 2015;42(4):781–96. Doi: http://dx.doi.org/10.1016/j.clp.2015.08.006
Sucasas Alonso A, Pértega Díaz S, Sáez Soto R, Ávila-Álvarez A. Epidemiología y factores de riesgo asociados a displasia broncopulmonar en prematuros menores de 32 semanas de edad gestacional. An Pediatría [Internet]. 2021;S1695-4033(21):00153-3. Doi: https://doi.org/10.1016/j.anpedi.2021.03.002
Sweet DG, Carnielli V, Greisen G, Hallman M, Ozek E, Te Pas A, et al. European Consensus Guidelines on the Management of Respiratory Distress Syndrome - 2019 Update. Neonatology [Internet]. 2019;115(4):432–50. Doi: https://doi.org/10.1159/000499361
Villamor-Martínez E, Pierro M, Cavallaro G, Mosca F, Villamor E. Mother’s own milk and bronchopulmonary dysplasia: A systematic review and meta-analysis. Front Pediatr [Internet]. 2019;7(JUN):1–9. Doi: https://doi.org/10.3389/fped.2019.00224
Patel AL, Johnson TJ, Robin B, Bigger HR, Buchanan A, Christian E, et al. Influence of own mother’s milk on bronchopulmonary dysplasia and costs. Arch Dis Child Fetal Neonatal Ed [Internet]. 2017;102(3):F256–F261. Doi: https://doi.org/10.1136/archdischild-2016-310898
Xu Y, Yu Z, Li Q, Zhou J, Yin X, Ma Y, et al. Dose-dependent effect of human milk on Bronchopulmonary dysplasia in very low birth weight infants. BMC Pediatr [Internet]. 2020;20(1):522. Doi: https://doi.org/10.1186/s12887-020-02394-1
Palencia D, Mendoza CJ, Torres J, Echandía CA. Kangaroo mother program: Physical growth and morbidity in a cohort of children, followed from 40 weeks of postconceptional age until first year. Colomb Med [Internet]. 2009;40(3):292–9. Disponible en: http://ref.scielo.org/tsnmv5
Seidman G, Unnikrishnan S, Kenny E, Myslinski S, Cairns-Smith S, Mulligan B, et al. Barriers and enablers of Kangaroo mother care practice: A systematic review. PLoS One [Internet]. 2015;10(5):e0125643. Doi: https://doi.org/10.1371/journal.pone.0125643
Tessier R, Charpak N, Giron M, Cristo M, De Calume ZF, Ruiz-Peláez JG. Kangaroo Mother Care, home environment and father involvement in the first year of life: A randomized controlled study. Acta Paediatr Int J Paediatr [Internet]. 2009;98(9):1444–50. Doi: https://doi.org/10.1111/j.1651-2227.2009.01370.x
Charpak N, Ruiz JG, Zupan J, Cattaneo A, Figueroa Z, Tessier R, et al. Kangaroo Mother Care: 25 Years after. Acta Paediatr Int J Paediatr [Internet]. 2005;94(5):514–22. Doi: https://doi.org/10.1111/j.1651-2227.2005.tb01930.x
Charpak N, Tessier R, Ruiz JG, Hernandez JT, Uriza F, Villegas J, et al. Twenty-year follow-up of kangaroo mother care versus traditional care. Pediatrics [Internet]. 2017;139(1):e20162063. Doi: https://doi.org/10.1542/peds.2016-2063
Poindexter BB, Martin CR. Impact of Nutrition on Bronchopulmonary Dysplasia. Clin Perinatol [Internet]. 2015;42(4):797–806. Doi: https://doi.org/10.1016/j.clp.2015.08.007
Lin F, Dong H, Song Y. Effect of bronchopulmonary dysplasia on the early intellectual development of preterm infants. Pediatr Int [Internet]. 2017;59(6):691–7. Doi: https://doi.org/10.1111/ped.13257
Haslam MD, Lisonkova S, Creighton D. Severe Neurodevelopmental Impairment in Neonates Born Preterm Impact of Varying Definitions in a Canadian Cohort. J Pediatr [Internet]. 2018;197:75–81.e4. Doi: https://doi.org/10.1016/j.jpeds.2017.12.020
Trittmann JK, Nelin LD, Klebanoff MA. Bronchopulmonary dysplasia and neurodevelopmental outcome in extremely preterm neonates. Eur J Pediatr [Internet]. 2013;172(9):1173–80. Doi: https://doi.org/10.1007/s00431-013-2016-5
Brumbaugh JE, Colaizy TT, Patel NM. The changing relationship between bronchopulmonary dysplasia and cognition in very preterm infants. Acta Paediatr [Internet]. 2018;107(8):1339–44. Doi: https://doi.org/10.1111/apa.14219
Rodriguez-Martinez CE, Acuña-Cordero R, Sossa-Briceño MP. Predictors of prolonged length of hospital stay or readmissions for acute viral lower respiratory tract infections among infants with a history of bronchopulmonary dysplasia [Internet]. Vol. 90, Journal of Medical Virology. 2018. p. 405–11. Doi: https://doi.org/10.1002/jmv.24962
Landry JS, Chan T, Lands L, Menzies D. Long-term impact of bronchopulmonary dysplasia on pulmonary function. Can Respir J [Internet]. 2011;18(5):265–70. Doi: https://doi.org/10.1155/2011/547948
Acuña-Cordero R, Sossa-Briceño MP, Rodríguez-Martínez CE. Predictors of hospitalization for acute lower respiratory infections during the first two years of life in a population of preterm infants with bronchopulmonary dysplasia. Early Hum Dev [Internet]. 2018;127:53–7. Doi: https://doi.org/10.1016/j.earlhumdev.2018.10.003
Smith VC, Zupancic JAF, McCormick MC, Croen LA, Greene J, Escobar GJ, et al. Rehospitalization in the first year of life among infants with bronchopulmonary dysplasia. J Pediatr [Internet]. 2004;144(6):799–803. Doi: https://doi.org/10.1016/j.jpeds.2004.03.026
Bui CB, Pang MA, Sehgal A, Theda C, Lao JC, Berger PJ, et al. Pulmonary hypertension associated with bronchopulmonary dysplasia in preterm infants. J Reprod Immunol [Internet]. 2017;124:21–9. Doi: https://doi.org/10.1016/j.jri.2017.09.013
Hansmann G, Sallmon H, Roehr CC, Kourembanas S, Austin ED, Koestenberger M. Pulmonary hypertension in bronchopulmonary dysplasia. Pediatr Res [Internet]. 2021;89(3):446–55. Doi: https://doi.org/10.1038/s41390-020-0993-4
Al-Ghanem G, Shah P, Thomas S, Banfield L, El Helou S, Fusch C, et al. Bronchopulmonary dysplasia and pulmonary hypertension: A meta-analysis. J Perinatol [Internet]. 2017;37(4):414–9. Doi: https://doi.org/10.1038/jp.2016.250
Pérez Tarazona S, Rueda Estaban S, Alfonso Diego S, Barrio MI, Callejon A, Cortell I, et al. Protocolo de seguimiento de los pacientes con displasia broncopulmonar. An Pediatr [Internet]. 2016;84(1):61.e1-61.e9. Doi: https://doi.org/10.1016/j.anpedi.2015.04.020