Fundamentos biomoleculares de la diabetes mellitus

Abstract

The diabetes mellitus is a endocrine disease with important implications at systemic level, like: angiophaties, neuropathies, retinopathies and nephropathies, among others. These complications have their origin in biomolecular events triggered by hyperglycemia. The present revision treats on the structure and insulin synthesis in the pancreatic beta cells; the molecular and biochemical events that activate their secretion as answer to a high glucose concentration in blood; the signaling pathway generated by the union of the insulin to its receptor on diane cells; and the metabolic alterations that the different types from diabetes mellitus produce.