Deficiencia de vitamina B12 y síntomas depresivos: una revisión narrativa de la literatura

Contenido principal del artículo

Feligno Alberto Barliza-Quintana
Cindy Alejandra Pachón

Resumen

La depresión tiene un origen complejo que involucra factores genéticos, neurofisiológicos, hormonales, psicosociales y ambientales. Existe una posible relación entre la deficiencia de vitamina B12 y la depresión, con indicios de que la suplementación puede aliviar los síntomas en adultos tratados con inhibidores selectivos de la recaptación de serotonina. Aunque se ha encontrado esta asociación, aún falta establecer una relación causal directa, lo que demanda investigaciones más rigurosas. Este artículo revisa y sintetiza la evidencia disponible sobre esta relación y sus implicaciones clínicas. Se requieren más estudios para confirmar la asociación, la detección en poblaciones de riesgo.

Descargas

Los datos de descargas todavía no están disponibles.

Detalles del artículo

Cómo citar
Barliza-Quintana, F. A., & Pachón, C. A. (2024). Deficiencia de vitamina B12 y síntomas depresivos: una revisión narrativa de la literatura. Duazary, 21(2), 148–157. https://doi.org/10.21676/2389783X.5828
Sección
Artículo de revisión

Citas

World Health Organization. Depressive disorder; 2023.

Valladares A, Dilla T, Sacristán JA. La depresión: una hipoteca social. Últimos avances en el conocimiento del coste de la enfermedad. Acta Esp Psiquiatr. 2009;37:49-53.

Remes O, Mendes JF, Templeton P. Biological, psychological, and social determinants of depression: A review of recent literature. Brain Sci. 2021;11:1633. https://doi.org/10.3390/brainsci11121633

McIntyre RS, Rong C, Subramaniapillai M, Lee Y. Trastorno depresivo mayor. Barcelona: Elsevier Health Sciences; 2020.

Pérez-Padilla EA, Cervantes-Ramírez VM, Hijuelos-García NA, Pineda-Cortés JC, Salgado-Burgos H. Prevalencia, causas y tratamiento de la depresión mayor. Rev Biomed. 2017;28:73-98. https://doi.org/10.32776/revbiomed.v28i2.557

Mikkelsen K, Stojanovska L, Apostolopoulos V. The effects of vitamin B in depression. Cur Med Chem. 2016;23:4317-37. https://doi.org/10.2174/0929867323666160920110810

Vargas-Upegui CD, Noreña-Rengifo D. Déficit de vitamina B12 en la práctica psiquiátrica. Iatreia. 2017;30:391-403. https://doi.org/10.17533/udea.iatreia.v30n4a04

Khosravi M, Sotoudeh G, Amini M, Raisi F, Mansoori A, Hosseinzadeh M. The relationship between dietary patterns and depression mediated by serum levels of folate and vitamin B12. BMC Psychiatry. 2020;20:1-8. https://doi.org/10.1186/s12888-020-2455-2

Tardy AL, Pouteau E, Marquez D, Yilmaz C, Scholey A. Vitamins and minerals for energy, fatigue and cognition: A narrative review of the biochemical and clinical evidence. Nutrients. 2020;12:228. https://doi.org/10.3390/nu12010228

de Oliveira Brito AM, de Lima Costa ASF, Oliveira SL, Machado AD, de Carvalho Pincinato E, Fuzaro CEM, Pereira IRO. Reposição de vitamina B12 reduz comportamento depressivo induzido em ratos jovens. Sci Med. 2016;26:11. https://doi.org/10.15448/1980-6108.2016.3.23499

Hutto BR. Folate and cobalamin in psychiatric illness. Compr Psychiatry. 1997;38:305-14. https://doi.org/10.1016/S0010-440X(97)90925-1

Bottiglieri T. Homocysteine and folate metabolism in depression. Prog Neuropsychopharmacol Biol Psychiatry. 2005;29:1103-12. https://doi.org/10.1016/j.pnpbp.2005.06.021

Güzelcan Y, van Loon P. Vitamin B12 status in patients of Turkish and Dutch descent with depression: A comparative cross-sectional study. Ann Gen Psychiatry. 2009;8:1-5. https://doi.org/10.1186/1744-859X-8-18

Ebesunun MO, Eruvulobi HU, Olagunju T, Owoeye OA. Elevated plasma homocysteine in association with decreased vitamin B12, folate, serotonin, lipids and lipoproteins in depressed patients. Afr J Psychiatry. 2012;15:25-9. https://doi.org/10.4314/ajpsy.v15i1.3

Gargari BP, Saboktakin M, Mahboob S, Pourafkari N. Nutritional status in patients with major depressive disorders: A pilot study in Tabriz, Iran. Health Promot Perspect. 2012;2:145. https://doi.org/10.5681%2Fhpp.2012.017

Kaner G, Soylu M, Yüksel N, Inanç N, Ongan D, Başmısırlı E. Evaluation of nutritional status of patients with depression. Biomed Res Int. 2015;2015:521481. https://doi.org/10.1155/2015/521481

Mikkelsen K, Stojanovska L, Prakash M, Apostolopoulos V. The effects of vitamin B on the immune/cytokine network and their involvement in depression. Maturitas. 2017;96:58-71. https://doi.org/10.1016/j.maturitas.2016.11.012

Schefft C, Kilarski LL, Bschor T, Koehler S. Efficacy of adding nutritional supplements in unipolar depression: A systematic review and meta-analysis. Eur Neuropsychopharmacol. 2017;27:1090-109. https://doi.org/10.1016/j.euroneuro.2017.07.004

Kapoor A, Baig M, Tunio SA, Memon AS, Karmani H. Neuropsychiatric and neurological problems among vitamin B12 deficient young vegetarians. Neurosci J. 2017;22:228-32. https://doi.org/10.17712/nsj.2017.3.20160445

Saraswathy KN, Ansari SN, Kaur G, Joshi PC, Chandel S. Association of vitamin B12 mediated hyperhomocysteinemia with depression and anxiety disorder: A cross-sectional study among Bhil indigenous population of India. Clin Nutr ESPEN. 2019;30:199-203. https://doi.org/10.1016/j.clnesp.2019.01.009

Berkins S, Schiöth HB, Rukh G. Depression and vegetarians: Association between dietary vitamin B6, B12 and folate intake and global and subcortical brain volumes. Nutrients. 2021;13:1790. https://doi.org/10.3390/nu13061790

Laird EJ, O’Halloran AM, Molloy AM, Healy M, Hernandez B, O’Connor DM, et al. Low vitamin B12 but not folate is associated with incident depressive symptoms in community-dwelling older adults: A 4-year longitudinal study. Br J Nutr. 2021;130:268-75. https://doi.org/10.1017/S0007114521004748

Sangle P, Sandhu O, Aftab Z, Anthony AT, Khan S. Vitamin B12 supplementation: Preventing onset and improving prognosis of depression. Cureus. 2020;12:e11169. https://doi.org/10.7759/cureus.11169

Syed EU, Wasay M, Awan S. Vitamin B12 supplementation in treating major depressive disorder: A randomized controlled trial. Open Neurol J. 2013;7:44. https://doi.org/10.2174%2F1874205X01307010044

Almeida OP, Ford AH, Hirani V, Singh V, McCaul K, Flicker L. B vitamins to enhance treatment response to antidepressants in middle-aged and older adults: Results from the B-VITAGE randomised, double-blind, placebo-controlled trial. Br J Psychiatry. 2014;205:450-7. https://doi.org/10.1192/bjp.bp.114.145177

Loikas S, Koskinen P, Irjala K, Löppönen M, Isoaho R, Kivelä SL, et al. Vitamin B12 deficiency in the aged: A population-based study. Age Ageing. 2007;36:177-83.https://doi.org/10.1093/ageing/afl150

Andrès E, Loukili NH, Noel E, Kaltenbach G, Abdelgheni MB, Perrin AE, et al. Vitamin B12 (cobalamin) deficiency in elderly patients. CMAJ. 2004;171:251-9. https://doi.org/10.1503/cmaj.1031155

Chávez Pacheco CE. Déficit de vitamina B12 y su correlación con la demencia y el deterioro cognitivo leve en adultos mayores. Bachelor's thesis. Quito: UCE; 2020. Se quitó el enlace web (no era doi).

Lachner C, Steinle NI, Regenold WT. The neuropsychiatry of vitamin B12 deficiency in elderly patients. J Neuropsychiatry Clin Neurosci. 2012;24:5-15. https://doi.org/10.1176/appi.neuropsych.11020052

Villamor E, Mora-Plazas M, Forero Y, Lopez-Arana S, Baylin A. Vitamin B-12 status is associated with socioeconomic level and adherence to an animal food dietary pattern in Colombian school children. J Nutr. 2008;138:1391-8. https://doi.org/10.1093/jn/138.7.1391

Brito A, Hertrampf E, Olivares M, Gaitan D, Sanchez H, Allen LH, Uauy R. Folate, vitamin B12 and human health. Rev Med Chil. 2012;140:1464-75. https://doi.org/10.4067/s0034-98872012001100014

Crellin R, Bottiglieri T, Reynolds EH. Folates and psychiatric disorders: Clinical potential. Drugs. 1993;45(5):623-36. https://doi.org/10.2165/00003495-199345050-00001

Naranjo-Santana YM. Actuación del laboratorio clínico para la mejora del manejo del déficit de vitamina B12 en atención primaria. Doctoral dissertation; 2016. Se quitó el enlace web (no era doi).

Lazarowski A. Transporte de vitamina B12: Un laberinto de una única entrada y múltiples caminos incompletos. Hematología. 2015;19:208-21.

Fumio W, Yoshihisa N. Comparative biochemistry of vitamin B12 (cobalamin) metabolism: biochemical diversity in the systems for intracellular cobalamin transfer and synthesis of the coenzymes. Int J Biochem. 1991;23:1353-9. https://doi.org/10.1016/0020-711X(91)90275-R

Forrellat-Barrios M, Gómis Hernández I, Gautier du Défaix Gómez H. Vitamina B12: metabolismo y aspectos clínicos de su deficiencia. Rev Cubana Hematol Inmunol Hemoter. 1999;15:159-74.

Boddington MM, Spriggs AI. The epithelial cells in megaloblastic anaemias. J Clin Pathol. 1959;12:228.

Rizzo G, Laganà AS, Rapisarda AMC, La Ferrera GMG, Buscema M, Rossetti P, et al. Vitamin B12 among vegetarians: status, assessment and supplementation. Nutrients. 2016;8:767. https://doi.org/10.3390/nu8120767

Castro R, Rivera I, Blom HJ, Jakobs C, De Almeida IT. Homocysteine metabolism, hyperhomocysteinaemia and vascular disease: an overview. J Inherit Metab Dis. 2006;29:3-20. https://doi.org/10.1007/s10545-006-0106-5

Selhub J. Homocysteine metabolism. Annu Rev Nutr. 1999;19:217-46. https://doi.org/10.1146/annurev.nutr.19.1.217

Friedman AN, Bostom AG, Selhub J, Levey AS, Rosenberg IH. The kidney and homocysteine metabolism. J Am Soc Nephrol. 2001;12:2181-9. https://doi.org/10.1681/ASN.V12102181

Green R, Allen LH, Bjørke-Monsen AL, Brito A, Guéant JL, Miller JW, et al. Vitamin B12 deficiency. Nat Rev Dis Primers. 2017;3:1-20. https://doi.org/10.1038/nrdp.2017.40

Moore E, Mander A, Ames D, Carne R, Sanders K, Watters D. Cognitive impairment and vitamin B12: a review. Int Psychogeriatr. 2012;24:541-56. https://doi.org/10.1017/S1041610211002511

Garlick PJ. Toxicity of methionine in humans. J Nutr. 2006;136:1722-5S. https://doi.org/10.1093/jn/136.6.1722S

Melgar AB, Becerril B, Gil T, Olivares J. Déficit de vitamina B12 en paciente tratado con metformina. Semergen. 2008;34:463-4. https://doi.org/10.1016/S1138-3593(08)75207-9

Stabler SP. Vitamin B12 deficiency. N Engl J Med. 2013;368:149-60. https://doi.org/10.1056/NEJMcp1113996

Martínez JD, Henao SC, Rey MH. Niveles de vitamina B12 en pacientes colombianos con gastritis crónica atrófica. Rev Colomb Gastroenterol. 2010;25:261-4.

Jauhar S, Blackett A, Srireddy P, McKenna PJ. Pernicious anaemia presenting as catatonia without signs of anaemia or macrocytosis. Br J Psychiatry. 2010;197:244-5. https://doi.org/10.1192/bjp.bp.108.054072

Butler CC, Vidal-Alaball J, Cannings-John R, McCaddon A, Hood K, Papaioannou A, et al. Oral vitamin B12 versus intramuscular vitamin B12 for vitamin B12 deficiency: A systematic review of randomized controlled trials. Fam Pract. 2006;23:279-85. https://doi.org/10.1093/fampra/cml008

Stahl SM, Muntner N, Grady MM. Psicofarmacología esencial de Stahl: bases neurocientíficas y aplicaciones prácticas. Mens Sana Monogr. 2010; 8:146-50.

Youssef MM, Underwood MD, Huang YY, Hsiung SC, Liu Y, Simpson NR, et al. Association of BDNF Val66Met polymorphism and brain BDNF levels with major depression and suicide. Int J Neuropsychopharmacol. 2018;21:528-38. https://doi.org/10.1093/ijnp/pyy008

Hing B, Sathyaputri L, Potash JB. A comprehensive review of genetic and epigenetic mechanisms that regulate BDNF expression and function with relevance to major depressive disorder. Am J Med Genet B Neuropsychiatr Genet. 2018;177:143-67. https://doi.org/10.1002/ajmg.b.32616

Pagoaga A, Interiano V, Reyes EN. Déficit de vitamina B12 y manifestaciones psiquiátricas. Rev Hond Postgrado Psiquiatr. 2016;10:47-52.

Ferrari AJ, Somerville AJ, Baxter AJ, Norman R, Patten SB, Vos T, et al. Global variation in the prevalence and incidence of major depressive disorder: A systematic review of the epidemiological literature. Psychol Med. 2013;43:471-81. https://doi.org/10.1017/S0033291712001511

Kessler RC, Berglund P, Demler O, Jin R, Koretz D, Merikangas KR, et al. The epidemiology of major depressive disorder: results from the National Comorbidity Survey Replication (NCS-R). JAMA. 2003;289:3095-105. https://doi.org/10.1001/jama.289.23.3095

Silverman JJ, Galanter M, Jackson-Triche M, Jacobs DG, Lomax JW, Riba MB, et al. The American Psychiatric Association practice guidelines for the psychiatric evaluation of adults. Am J Psychiatry. 2015;172:798-802. https://doi.org/10.1176/appi.ajp.2015.1720501

MedlinePlus. Prueba de homocisteína. Bethesda (MD): Biblioteca Nacional de Medicina de EE. UU.